Lapatinib ditosylate
Cat. No.：YN340246
CAS No. ：388082-77-7
| 产品名称: | Lapatinib ditosylate |
| CAS No.: | 388082-77-7 |
| Chemical Name: | N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate; GW-572016F Ditosylate; Tykerb Ditosylate; |
| Synonyms: | 二甲苯磺酸拉帕替尼; GW572016 ditosylate; GW2016 ditosylate |
| 分子量: | 925.46 |
| 分子式: | C₄₃H₄₂ClFN₄O₁₀S₃ |
| SMILES: | O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O.O=S(C6=CC=C(C)C=C6)(O)=O.O=S(C7=CC=C(C)C=C7)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lapatinib ditosylate (GW572016 ditosylate) 是一种ErbB-2和EGFR酪氨酸激酶结构域的有效抑制剂，对纯化的EGFR和ErbB-2的IC50值分别为 10.2 和 9.8 nM。 |
| IC50和靶点: | [{name:"EGFR:10.8 nM (IC50, Cell Free Assay)"},{name: "ErbB2:9.2 nM (IC50, Cell Free Assay)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kim, T.E., et al.: Drugs, 6, 886 (2003)
Wood, E.R., et al.: Cancer Res., 64, 6652 (2004)
Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),
