Mutated EGFR-IN-1
Cat. No.：YN340247
CAS No. ：1421372-66-8
| 产品名称: | Mutated EGFR-IN-1 |
| CAS No.: | 1421372-66-8 |
| Chemical Name: | N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine |
| Synonyms: | Osimertinib analog |
| 分子量: | 445.56 |
| 分子式: | C₂₅H₃₁N₇O |
| SMILES: | NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mutated EGFR-IN-1 (Osimertinib analog) 是突变型EGFR(L858R EGFR，Exonl9缺失活化突变和T790M抗性突变) 抑制剂的中间体。 |
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Finlay, M.R., Anderton, M., Ashton, S., et al.Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptorJ. Med. Chem.57(20),8249-8267(2014)
