Lavendustin C
Cat. No.：YN340295
| 产品名称: | Lavendustin C |
| CAS No.: | 125697-93-0 |
| Chemical Name: | 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid |
| Synonyms: | NSC 666251,HDBA,N-(2,5-二羟基苄基)-5-氨基水杨酸 |
| 分子量: | 275.26 |
| 分子式: | C₁₄H₁₃NO₅ |
| SMILES: | O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lavendustin C 是一种有效的 Ca2+钙调蛋白依赖性激酶 II (CaMK II) 抑制剂，IC50为 0.2 µM。Lavendustin C 抑制EGFR相关酪氨酸激酶 (IC50=0.012 µM) 和pp60c-src(+)激酶 (IC50=0.5 µM)。 |
| IC50和靶点: | [{name:"CaMK II:0.2 μM (IC50)"},{name: "EGFR:0.012 μM (IC50)"}] |
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Onoda, T., Iinuma, H., Sasaki, Y., et al.Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendusJ. Nat. Prod.52(6),1252-1257(1989)
O'Dell, T.J., Kandel, E.R., and Grant, S.G.N.Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitorsNature353,558-560(1991)
Burt, H.M., Jackson, J.K., and Salari, H.Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitorJ. Leukoc. Biol.55,112-119(1994)
