PF-6274484
Cat. No.：YN340296
CAS No. ：1035638-91-5
| 产品名称: | PF-6274484 |
| CAS No.: | 1035638-91-5 |
| Chemical Name: | N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide |
| Synonyms: | PF-6274484 |
| 分子量: | 372.8 |
| 分子式: | C18H14ClFN4O2 |
| SMILES: | FC1=C(Cl)C=C(NC2=NC=NC3=C2C=C(NC(C=C)=O)C(OC)=C3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-6274484 是一种有效的EGFR抑制剂，对于 EGFR-L858R/T790M 和 WT-EGFR，Kis 分别为 0.14 nM 和 0.18 nM。PF-6274484 在 H1975 肿瘤细胞和 A549 肿瘤细胞中抑制EGFR-L858R/T790M自身磷酸化和EGFR-WT，IC50分别为6.6和5.8 nM。 |
| IC50和靶点: | [{name:"EGFR (WT):0.18 nM (Ki)"},{name: "EGFRL858R/T790M:0.14 nM (Ki)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Schwartz, P.A., Kuzmic, P., Solowiej, J., et al.Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistanceProc. Natl. Acad. Sci. USA111(1),173-178(2014)
