DBPR112
Cat. No.：YN340300
CAS No. ：1226549-49-0
| 产品名称: | DBPR112 |
| CAS No.: | 1226549-49-0 |
| Chemical Name: | |
| Synonyms: | DBPR112;BDBM50530623;(E)-4-(dimethylamino)-N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-y |
| 分子量: | 533.62 |
| 分子式: | C32H31N5O3 |
| SMILES: | O1C2C(=C(N=C([H])N=2)N([H])[C@]([H])(C([H])([H])O[H])C2C([H])=C([H])C([H])=C([H])C=2[H])C(C2C([H])=C([H])C([H])=C(C=2[H])N([H])C(/C(/[H])=C(\[H])/C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=O)=C1C1C([H])=C([H])C([H])=C([H])C=1[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DBPR112 是一种口服有效的基于氟嘧啶的EGFR抑制剂，对EGFRWT和EGFRL858R/T790M的IC50分别为 15 nM 和 48 nM。DBPR112 可以占据 ATP 结合位点。DBPR112 具有显着的抗肿瘤功效。 |
| IC50和靶点: | [{name:"EGFRL858R/T790M:48 nM (IC50)"},{name: "EGFRWT:15 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
