(E)-AG 556
Cat. No.：YN340303
CAS No. ：133550-41-1
| 产品名称: | (E)-AG 556 |
| CAS No.: | 133550-41-1 |
| Chemical Name: | (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide |
| Synonyms: | |
| 分子量: | 336.38448 |
| 分子式: | C20H20N2O3 |
| SMILES: | O=C(NCCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC(O)=C(C=C2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E)-AG 556 是一种高选择性的EGFR抑制剂，并阻断 LPS 诱导的促炎因子 TNF-α 的产生。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gazit, A., Osherov, N., Posner, I., et al.Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinasesJ. Med. Chem.34(6),1896-1907(1991)
Toda, T., Yamamoto, S., Yonezawa, R., et al.Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activationEur. J. Pharmacol.786,19-28(2016)
Brenner, T., Poradosu, E., Soffer, D., et al.Suppression of experimental autoimmune encephalomyelitis by tyrphostin AG-556Exp. Neurol.154(2),489-498(1998)
Genovese, T., Mazzon, E., Esposito, E., et al.Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord traumaNeuropharmacology52(7),1454-1471(2007)
