Avitinib
Cat. No.：YN340307
CAS No. ：1557267-42-1
| 产品名称: | Avitinib |
| CAS No.: | 1557267-42-1 |
| Chemical Name: | N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide |
| Synonyms: | 艾维替尼; Abivertinib; AC0010 |
| 分子量: | 487.5 |
| 分子式: | C26H26FN7O2 |
| SMILES: | CN1CCN(C2=C(F)C=C(NC3=NC(OC4=CC(NC(C=C)=O)=CC=C4)=C(C=CN5)C5=N3)C=C2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Avitinib (Abivertinib) 是第三代、不可逆、具有口服活性的选择性EGFR抑制剂，针对EGFRL858R、EGFRT790M和野生型EGFR的IC50值为 0.18 nM、0.18 nM、7.68 nM。Avitinib 也是一种BTK抑制剂，可诱导套细胞淋巴瘤细胞凋亡 (apoptosis) 并抑制BTK磷酸化。Avitinib 显示出抗癌作用。 |
| IC50和靶点: | [{name:"EGFR L858R:0.18 nM (IC50)"},{name: "EGFRT790M:0.18 nM (IC50)"},{name: "EGFR (WT):7.68 nM (IC50)"}] |
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Xu, X., Mao, L., Xu, W., et al.AC0010, an irreversible EGFR inhibitor selectively targeting mutated EGFR and overcoming T790M-induced resistance in animal models and lung cancer patientsMol. Cancer Ther.15(11),2586-2597(2016)
