(S)-Sunvozertinib
Cat. No.：YN340316
CAS No. ：2370013-49-1
| 产品名称: | (S)-Sunvozertinib |
| CAS No.: | 2370013-49-1 |
| Chemical Name: | |
| Synonyms: | DZD9008 |
| 分子量: | 584.08 |
| 分子式: | C29H35ClFN7O3 |
| SMILES: | COC1=C(NC2=NC=CC(=N2)NC3=CC(=C(F)C=C3C(C)(C)O)Cl)C=C(NC(=O)C=C)C(=C1)N4CCC(C4)N(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-Sunvozertinib ((S)-DZD9008) 是 Sunvozertinib 的 S-对映体，对EGFR外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变和 Her2 外显子 20 YVMA 插入具有抑制活性 (IC50分别为 51.2 nM、51.9 nM、1 nM 和 21.2 nM)。(S)-Sunvozertinib 也抑制BTK。 |
| IC50和靶点: | [{name:"EGFR exon 20 NPH:51.2 nM (IC50)"},{name: "EGFR exon 20 ASV insertion:51.9 nM (IC50)"},{name: "EGFRL858R/T790M:1 nM (IC50)"},{name: "Her2 exon 20 YVMA insertion:21.2 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
