SMI-4a
Cat. No.：YN340323
CAS No. ：438190-29-5
| 产品名称: | SMI-4a |
| CAS No.: | 438190-29-5 |
| Chemical Name: | 5Z-[[3-(trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| Synonyms: | TCS-PIM-1-4a |
| 分子量: | 273.2 |
| 分子式: | C11H6F3NO2S |
| SMILES: | O=C(NC(S/1)=O)C1=C\C2=CC=CC(C(F)(F)F)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SMI-4a (TCS-PIM-1-4a) 是一种有效的，选择性的，细胞可渗透的且具有 ATP 竞争性的Pim-1抑制剂，其IC50为 24 μM，Ki为 0.6 μM。SMI-4a 还抑制Pim-2(IC50为 100 μM)，并且不显着抑制其他丝氨酸/苏氨酸或酪氨酸激酶。SMI-4a 具有抗癌活性。 |
| IC50和靶点: | [{name:"PIM1:24 μM (IC50)"},{name: "PIM1:0.6 μM (Ki)"},{name: "PIM2:100 μM (IC50)"}] |
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| Solvent & Solubility: |
Beharry, Z., Mahajan, S., Zemskova, M., et al.The Pim protein kinases regulate energy metabolism and cell growthProc. Natl. Acad. Sci. USA108(2),528-533(2011)
Lin, Y.W., Beharry, Z.M., Hill, E.G., et al.A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphomaBlood115(4),824-833(2010)
