JNJ28871063 hydrochloride
Cat. No.：YN340335
| 产品名称: | JNJ28871063 hydrochloride |
| CAS No.: | 944342-90-9 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 519.42 |
| 分子式: | C24H28Cl2N6O3 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ28871063 hydrochloride 是一种口服有效、高选择性和 ATP 竞争性的pan-ErbB激酶抑制剂，对 ErbB1、ErbB2 和 ErbB4 的IC50值分别为 22 nM、38 nM 和 21 nM。JNJ28871063 hydrochloride 抑制EGFR和 ErbB2 中具有重要功能的酪氨酸残基的磷酸化。JNJ28871063 hydrochloride 可以透过血脑屏障，在过表达EGFR和 ErbB2 的人类肿瘤异种移植模型中具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"ErbB1:22 nM (IC50)"},{name: "ErbB2:38 nM (IC50)"},{name: "ErbB4:21 nM (IC50)"}] |
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