CHMFL-EGFR-202
Cat. No.：YN340348
| 产品名称: | CHMFL-EGFR-202 |
| CAS No.: | 2089381-40-6 |
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| 分子量: | 489.96 |
| 分子式: | C25H24ClN7O2 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHMFL-EGFR-202 是一种有效、不可逆的表皮生长因子受体(EGFR)突变型激酶抑制剂， 对 耐药突变型EGFRT790M 和 WTEGFR激酶作用的IC50值分别为 5.3 nM 和 8.3 nM。在细胞中，CHMFL-EGFR-202 对EGFRL858R/T790M 的选择性是EGFR野生型的 10 倍。CHMFL-EGFR-202 以 “DFG-in-C-helix-out” 的不活跃结合构象形式共价结合EGFR，对EGFR突变体驱动的非小细胞肺癌 (NSCLC) 细胞株具有较强的抗增殖 |
| IC50和靶点: | [{name:"EGFRT790M:5.3 nM (IC50)"},{name: "EGFR:8.3 nM (IC50)"},{name: "ErbB2:8.1 nM (IC50)"},{name: "ErbB4:3.2 nM (IC50)"},{name: "MEK1:161 nM (IC50)"},{name: "Btk:24.5 nM (IC50)"},{name: "BLK:8.1 nM (IC50)"},{name: "BMX:111 nM (IC50)"}] |
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