PRN1371
Cat. No.：YN440042
CAS No. ：1802929-43-6
规格
价格(RMB)
库存
| 产品名称: | PRN1371 |
| CAS No.: | 1802929-43-6 |
| Chemical Name: | 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]propyl]-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Synonyms: | |
| 分子量: | 561.46 |
| 分子式: | C₂₆H₃₀Cl₂N₆O₄ |
| SMILES: | O=C1C(C2=C(Cl)C(OC)=CC(OC)=C2Cl)=CC3=CN=C(NC)N=C3N1CCCN4CCN(C(C=C)=O)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PRN1371 是高度选择性和有效的FGFR1-4和CSF1R抑制剂，对FGFR1，FGFR2，FGFR3，FGFR4 和 CSF1R 的IC50值分别为 0.6，1.3，4.1，19.3 和 8.1 nM。 |
| IC50和靶点: | [{name:"FGFR1:0.6 nM (IC50)"},{name: "FGFR2:1.3 nM (IC50)"},{name: "FGFR3:4.1 nM (IC50)"},{name: "FGFR4:19.3 nM (IC50)"},{name: "CSF1R:8.1 nM (IC50)"}] |
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| Solvent & Solubility: |
Venetsanakos, E., Brameld, K.A., Phan, V.T., et al.The irreversible covalent fibroblast growth factor receptor inhibitor PRN1371 exhibits sustained inhibition of FGFR after drug clearanceMol. Cancer Ther.16(12),2668-2676(2017)
