OSI-930
Cat. No.：YN440058
CAS No. ：728033-96-3
规格
价格(RMB)
库存
| 产品名称: | OSI-930 |
| CAS No.: | 728033-96-3 |
| Chemical Name: | 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide |
| Synonyms: | OSI 930,噻尔非尼 |
| 分子量: | 443.44 |
| 分子式: | C₂₂H₁₆F₃N₃O₂S |
| SMILES: | O=C(C1=C(NCC2=CC=NC3=CC=CC=C23)C=CS1)NC4=CC=C(OC(F)(F)F)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OSI-930是Kit，KDR和CSF-1R的抑制剂，IC50分别为80 nM，9 nM和15 nM，对Flt-1，c-Raf和Lck有接近的抑制性，但对 PDGFRα/β，Flt-3和Abl抑制性较弱。 |
| IC50和靶点: | [{name:"KDR:9 nM (IC50)"},{name: "Flt-1:8 nM (IC50)"},{name: "Kit:80 nM (IC50)"},{name: "PDGFRβ:6900 nM (IC50)"},{name: "PDGFRα:3408 nM (IC50)"},{name: "CSF-1R:15 nM (IC50)"},{name: "c-Raf:41 nM (IC50)"},{name: "Flt-3:1303 nM (IC50)"},{name: "Lck:22 nM (IC50)"},{name: "Abl:4738 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Garton, A.J., Crew, A.P.A., Franklin, M.C., et al.OSI-930: A novel selective inhibitor of kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft modelsCancer Res.66(2),1015-1024(2006)
