Ki20227
Cat. No.：YN440092
CAS No. ：623142-96-1
规格
价格(RMB)
库存
| 产品名称: | Ki20227 |
| CAS No.: | 623142-96-1 |
| Chemical Name: | N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]-urea |
| Synonyms: | KI-20227 |
| 分子量: | 480.54 |
| 分子式: | C₂₄H₂₄N₄O₅S |
| SMILES: | O=C(NC1=CC=C(C=C1OC)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC(C)C4=NC=CS4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ki20227 是一种口服有效，高选择性CSF1R(c-Fms 酪氨酸激酶)抑制剂，对 CSF1R，VEGFR2(血管内皮生长因子受体 2)，c-Kit(干细胞因子受体) 和PDGFRβ(血小板衍生的生长因子受体 β) 的IC50分别为 2 nM，12 nM，451 nM 和 217 nM。Ki20227 可以抑制破骨细胞分化和溶骨性破坏。 |
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Ohno, H., Kubo, K., Murooka, H., et al.A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis modelMol. Cancer Ther.5(11),2634-2643(2006)
Ohno, H., Uemura, Y., Murooka, H., et al.The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse modelEur. J. Immunol.38(1),283-291(2008)
