Edicotinib
Cat. No.：YN440120
CAS No. ：1142363-52-7
规格
价格(RMB)
库存
| 产品名称: | Edicotinib |
| CAS No.: | 1142363-52-7 |
| Chemical Name: | 5-cyano-N-[2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(tetrahydro-2,2,6,6-tetramethyl-2H-pyran-4-yl)-3-pyridinyl]-1H-imidazole-2-carboxamide |
| Synonyms: | JNJ-40346527; JNJ-527 |
| 分子量: | 461.60 |
| 分子式: | C₂₇H₃₅N₅O₂ |
| SMILES: | O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Edicotinib (JNJ-40346527) 是一种有效的、选择性的、具有血脑通透性和口服活性CSF-1R抑制剂，IC50为 3.2 nM。Edicotinib 对 KIT 和 FLT3 的抑制作用较小，IC50值分别为 20 nM 和 190 nM。Edicotinib 抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。Edicotinib 可以用于阿尔茨海默病和类风湿性关节炎的研究。 |
| IC50和靶点: | |
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Mancuso, R., Fryatt, G., Cleal, M., et al.CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S miceBrain142(10),3243-3264(2019)
Manthey, C.L., Moore, B.A., Chen, Y., et al.The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitisPLoS One14(11),e0223918(2019)
Campion, L., Deangelis, N., Ferrante, C., et al.Abstract B269: Effects of blocking aberrantly expressed CSF-1R in Hodgkin lymphomaMol. Cancer Ther.12(11_Supplement),B269(2014)
