GW2580
Cat. No.：YN440124
CAS No. ：870483-87-7
规格
价格(RMB)
库存
| 产品名称: | GW2580 |
| CAS No.: | 870483-87-7 |
| Chemical Name: | 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine |
| Synonyms: | SC-203877 |
| 分子量: | 366.41 |
| 分子式: | C₂₀H₂₂N₄O₃ |
| SMILES: | NC1=NC(N)=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW2580 是口服有效的，选择性的c-Fms激酶抑制剂，体外实验中在 0.06 μM 时可完全抑制人 cFMS 激酶。GW2580 是 ATP 与 cFMS 激酶结合的竞争性抑制剂，并且可以抑制集落刺激因子 1 信号传导。 |
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Conway, J.G., Pink, H., Bergquist, M.L., et al.Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic ratsJ. Pharmacol. Exp. Ther.326(1),41-50(2008)
