PLX5622
Cat. No.：YN440164
CAS No. ：1303420-67-8
规格
价格(RMB)
库存
| 产品名称: | PLX5622 |
| CAS No.: | 1303420-67-8 |
| Chemical Name: | 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine |
| Synonyms: | PLX-5622 |
| 分子量: | 395.41 |
| 分子式: | C₂₁H₁₉F₂N₅O |
| SMILES: | COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PLX5622 是高度选择性的、能透过血脑屏障的、口服有效的CSF1R抑制剂，Ki值为 5.9 nM，可用于病程发展前和过程中，扩大的和特异性的小胶质细胞的消除。PLX5622 具有较好的药理学特性。 |
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| Solvent & Solubility: |
Spangenberg, E., Severson, P.L., Hohsfield, L.A., et al.Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease modelNat. Commun.10(1),3758(2019)
Lee, S., Shi, X.Q., Fan, A., et al.Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic painMol. Pain14,(2018)
