Pazopanib Hydrochloride
Cat. No.：YN440178
CAS No. ：635702-64-6
规格
价格(RMB)
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| 产品名称: | Pazopanib Hydrochloride |
| CAS No.: | 635702-64-6 |
| Chemical Name: | GW 786034B; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride; Votrient Hydrochloride; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide Hydro |
| Synonyms: | 盐酸帕唑帕尼; GW786034 (Hydrochloride) |
| 分子量: | 473.98 |
| 分子式: | C₂₁H₂₄ClN₇O₂S |
| SMILES: | CC1=CC=C(C=C1S(N)(=O)=O)NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C)C)=N2.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pazopanib Hydrochloride (GW786034 Hydrochloride) 是多靶点抑制剂，抑制VEGFR1，VEGFR2，VEGFR3，PDGFRβ，c-Kit，FGFR1，c-Fms的IC50分别为10，30，47，84，74，140，146 nM。 |
| IC50和靶点: | [{name:"VEGFR1:10 nM (IC50)"},{name: "VEGFR2:30 nM (IC50)"},{name: "VEGFR3:47 nM (IC50)"},{name: "PDGFRβ:84 nM (IC50)"},{name: "FGFR1:140 nM (IC50)"},{name: "c-Kit:74 nM (IC50)"},{name: "c-Fms:146 nM (IC50)"}] |
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| Solvent & Solubility: |
Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),
