BLZ945
Cat. No.：YN440223
CAS No. ：953769-46-5
规格
价格(RMB)
库存
| 产品名称: | BLZ945 |
| CAS No.: | 953769-46-5 |
| Chemical Name: | 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide |
| Synonyms: | BLZ945 |
| 分子量: | 398.48 |
| 分子式: | C₂₀H₂₂N₄O₃S |
| SMILES: | O=C(C1=NC=CC(OC2=CC=C3N=C(N[C@H]4[C@H](O)CCCC4)SC3=C2)=C1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BLZ945 是一种有效，选择性和脑渗透性的CSF-1R (c-Fms)抑制剂，IC50为 1 nM，选择性是其他受体酪氨酸激酶同系物的 1000 倍。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Pyonteck, S.M., Akkari, L., Schuhmacher, A.J., et al.CSF-1R inhibition alters macrophage polarization and blocks glioma progressionNat Med.19(10),1264-1272(2013)
Strachan, D.C., Ruffell, B., Oei, Y., et al.CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cellsOncoimmunology2(12),(2013)
