PLX647
Cat. No.：YN440293
CAS No. ：873786-09-5
规格
价格(RMB)
库存
| 产品名称: | PLX647 |
| CAS No.: | 873786-09-5 |
| Chemical Name: | 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine |
| Synonyms: | PLX 647,PLX-647 |
| 分子量: | 382.38 |
| 分子式: | C₂₁H₁₇F₃N₄ |
| SMILES: | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=CC=C43)C=C2)C=C1)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PLX647 是一种高度特异性的，具有口服活性的FMS和KIT双激酶抑制剂，IC50分别为 28 和 16 nM。PLX647 (1 μM) 在 400 个激酶组中显示出对 FMS 和 KIT 有选择性，但 FLT3 和 KDR 除外 (IC50=91 和 130 nM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zhang, C., Ibrahim, P.N., Zhang, J., et al.Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitorProc. Natl. Acad. Sci. USA110(14),5689-5694(2013)
