Linifanib
Cat. No.：YN440404
CAS No. ：796967-16-3
规格
价格(RMB)
库存
| 产品名称: | Linifanib |
| CAS No.: | 796967-16-3 |
| Chemical Name: | N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N’-(2-fluoro-5-methylphenyl)-urea |
| Synonyms: | ABT-869; AL-39324 |
| 分子量: | 375.40 |
| 分子式: | C₂₁H₁₈FN₅O |
| SMILES: | O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Linifanib (ABT-869) 是一种高效、口服的VEGFR和PDGFR家族多靶点抑制剂，对 KDR、FLT1、PDGFRβ、FLT3 的IC50s 分别为 4、3、66、4 nM。Linifanib (ABT-869) 具有显著的抗肿瘤活性。Linifanib (ABT-869) 对无关 RTKs、可溶性酪氨酸激酶或丝氨酸/苏氨酸激酶的活性要低得多。 |
| IC50和靶点: | [{name:"Flt-1:3 nM (IC50)"},{name: "KDR:4 nM (IC50)"},{name: "PDGFRβ:66 nM (IC50)"},{name: "FLT3:4 nM (IC50)"},{name: "CSF-1R:3 nM (IC50)"},{name: "Kit:14 nM (IC50)"}] |
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Albert, D.H., Tapang, P., Magoc, T.J., et al.Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitorMol. Cancer Ther.5(4),995-1006(2006)
Shankar, D.B., Li, J., Tapang, P., et al.ABT-869, a multitargeted receptor tyrosine kinase inhibitor: Inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemiaBlood109,3400-3408(2007)
