ISCK03
Cat. No.：YN440030
CAS No. ：945526-43-2
规格
价格(RMB)
库存
| 产品名称: | ISCK03 |
| CAS No.: | 945526-43-2 |
| Chemical Name: | 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-benzenesulfonamide |
| Synonyms: | N-(4-imidazol-1-yl phenyl)sulfonamide |
| 分子量: | 355.45 |
| 分子式: | C₁₉H₂₁N₃O₂S |
| SMILES: | O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=CC=C(N3C=CN=C3)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ISCK03是特异性的SCF/c-Kit抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Griswold, I.J., Shen, L.J., La Rosée, P., et al.Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesisBlood104(9),2912-2918(2004)
Wisniewski, D., Lambek, C.L., Liu, C., et al.Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinasesCancer Res.62(15),4244-4255(2002)
Na, Y.J., Baek, H.S., Ahn, S.M., et al.[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigsBiochem. Pharmacol.74(5),780-786(2007)
Kamlah, F., Hänze, J., Arenz, A., et al.Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cellsInt. J. Radiat. Oncol. Biol. Phys.80(5),1541-1549(2011)
Kon, S., Minegishi, N., Tanabe, K., et al.Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasiaJ. Clin. Invest.123(3),1123-1137(2013)
Herraiz, C., Journé, F., Abdel-Malek, Z., et al.Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKITMol. Endocrinol.25(1),138-156(2011)
