Tandutinib
Cat. No.：YN440056
CAS No. ：387867-13-2
规格
价格(RMB)
库存
| 产品名称: | Tandutinib |
| CAS No.: | 387867-13-2 |
| Chemical Name: | 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide |
| Synonyms: | 坦度替尼; MLN518; CT53518 |
| 分子量: | 562.70 |
| 分子式: | C₃₁H₄₂N₆O₄ |
| SMILES: | O=C(N1CCN(C2=C(C(C=C3OCCCN4CCCCC4)=NC=N2)C=C3OC)CC1)NC5=CC=C(OC(C)C)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tandutinib (MLN518) 是一种有效和选择性的FLT3的抑制剂，其IC50为 0.22 μM，并且还抑制c-Kit和PDGFR，其IC50分别为 0.17 μM 和 0.20 μM。Tandutinib 可用于急性骨髓性白血病，并具有穿越血脑屏障的能力。 |
| IC50和靶点: | [{name:"PDGFR:0.2 μM (IC50)"},{name: "FLT3:0.22 μM (IC50)"},{name: "c-Kit:0.17 μM (IC50)"}] |
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| Solvent & Solubility: |
Kelly, L.M., Yu, J.C., Boulton, C.L., et al.CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)Cancer Cell.1(5),421-432(2002)
Pandey, A., Volkots, D.L., Seroogy, J.M., et al.Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase familyJ. Med. Chem.45(17),3772-3793(2002)
Griswold, I.J., Shen, L.J., La Rosée, P., et al.Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesisBlood104(9),2912-2918(2004)
Ponnurangam, S., Standing, D., Rangarajan, P., et al.Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growthMol. Cancer Ther.12(5),598-609(2013)
Deng, W., Dai, C.L., Chen, J.J., et al.Tandutinib (MLN518) reverses multidrug resistance by inhibiting the efflux activity of the multidrug resistance protein 7 (ABCC10)Oncol. Rep.29(6),2479-2485(2013)
