Amuvatinib
Cat. No.：YN440060
CAS No. ：850879-09-3
规格
价格(RMB)
库存
| 产品名称: | Amuvatinib |
| CAS No.: | 850879-09-3 |
| Chemical Name: | N-(1,3-benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide |
| Synonyms: | MP470; HPK 56 |
| 分子量: | 447.51 |
| 分子式: | C₂₃H₂₁N₅O₃S |
| SMILES: | S=C(N1CCN(C2=C3OC4=CC=CC=C4C3=NC=N2)CC1)NCC5=CC=C6OCOC6=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂，对突变c-Kit，PDGFRα，Flt3，c-Met和c-Ret具有有效活性。Amuvatinib (MP470) 还是一种 DNA 修复抑制剂，靶向蛋白 DNA 修复RAD51，从而破坏 DNA 损伤修复。具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PDGFRαV561D:40 nM (IC50)"},{name: "PDGFRαD842V:81 nM (IC50)"},{name: "c-KitD816H:10 nM (IC50)"},{name: "c-KitV560G:34 nM (IC50)"},{name: "c-KitV654A:127 nM (IC50)"},{name: "c-KitD816V:950 nM (IC50)"}] |
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| Solvent & Solubility: |
Qi, W., Cooke, L.S., Stejskal, A., et al.MP470, a novel receptor tyrosine kinase inhibitor, in combination with erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancerBMC Cancer9(142),1-12(2009)
Padda, S., Neal, J.W., and Wakelee, H.A.MET inhibitors in combination with other therapies in non-small cell lung cancerTransl. Lung Cancer Res.1(4),238-253(2012)
Welsh, J.W., Mahadevan, D., Ellsworth, R., et al.The c-Metreceptortyrosine kinaseinhibitor MP470 radiosensitizes glioblastomacellsRadiat. Oncol.4(69),(2009)
Zhao, H., Luoto, K.R., Meng, A.X., et al.The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombinationRadiother. Oncol.101(1),59-65(2011)
