Dovitinib lactate
Cat. No.：YN440061
CAS No. ：692737-80-7
规格
价格(RMB)
库存
| 产品名称: | Dovitinib lactate |
| CAS No.: | 692737-80-7 |
| Chemical Name: | 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-Hydroxypropanoic Acid; CHIR 258; TKI 258; |
| Synonyms: | 多韦替尼乳酸盐; CHIR-258 lactate; TKI-258 lactate |
| 分子量: | 482.51 |
| 分子式: | C₂₄H₂₇FN₆O₄ |
| SMILES: | O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dovitinib lactate (TKI258 lactate) 是多靶点的酪氨酸激酶抑制剂，抑制FLT3，c-Kit，FGFR1/3，VEGFR1/2/3和PDGFRα/β的IC50值分别为 1，2，8/9，10/13/8，27/210 nM。 |
| IC50和靶点: | [{name:"FLT3:1 nM (IC50)"},{name: "c-Kit:2 nM (IC50)"},{name: "FGFR1:8 nM (IC50)"},{name: "FGFR3:9 nM (IC50)"},{name: "VEGFR1:1 nM (IC50)"},{name: "VEGFR3:8 nM (IC50)"},{name: "VEGFR2:13 nM (IC50)"},{name: "PDGFRα:27 nM (IC50)"},{name: "PDGFRβ:210 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Renhowe, P., et al.: J. Med. Chem., 52, 278 (2009),
