Masitinib
Cat. No.：YN440063
CAS No. ：790299-79-5
规格
价格(RMB)
库存
| 产品名称: | Masitinib |
| CAS No.: | 790299-79-5 |
| Chemical Name: | 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-benzamide |
| Synonyms: | 马赛替尼; AB1010 |
| 分子量: | 498.64 |
| 分子式: | C₂₈H₃₀N₆OS |
| SMILES: | O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Masitinib (AB1010) 是一种有效的，生物口服可利用的，且选择性的c-Kit抑制剂 (对于人重组c-Kit，IC50=200 nM)，它还抑制PDGFRα/β(IC50s=540/800 nM)，Lyn(对 LynB 的IC50=510 nM)，Lck，较小程度上抑制FGFR3和FAK。Masitinib (AB1010) 有抗增殖，促凋亡活性，且毒性低。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Dubreuil, P., Letard, S., Ciufolini, M., et al.Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KITPLoS One4(9),e7258(2009)
Drayman, N., DeMarco, J.K., Jones, K.A., et al.Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2Science373(6557),931-936(2021)
