Toceranib
Cat. No.：YN440077
CAS No. ：356068-94-5
规格
价格(RMB)
库存
| 产品名称: | Toceranib |
| CAS No.: | 356068-94-5 |
| Chemical Name: | 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide |
| Synonyms: | 托西尼布; SU11654; PHA 291639E |
| 分子量: | 396.46 |
| 分子式: | C₂₂H₂₅FN₄O₂ |
| SMILES: | O=C(NCCN1CCCC1)C2=C(NC(/C=C3C(NC4=C\3C=C(C=C4)F)=O)=C2C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Toceranib (SU11654) 是一种口服活性受体酪氨酸激酶 (RTK) 抑制剂，能有效抑制PDGFR，VEGFR，Kit，抑制 PDGFRβ 和 Flk-1/KDR 的Ki值分别为 5 nM 和 6 nM。Toceranib 具有抗肿瘤和抗血管生成活性，用于犬肥大细胞肿瘤的研究。 |
| IC50和靶点: | [{name:"PDGFRβ:5 nM (Ki)"},{name: "Flk-1:6 nM (Ki)"}] |
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| Solvent & Solubility: |
Liao, A.T., Chien, M.B., Shenoy, N., et al.Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitorsBlood100(2),585-593(2002)
London, C., Mathie, T., Stingle, N., et al.Preliminary evidence for biologic activity of toceranib phosphate (Palladiar) in solid tumoursVet. Comp. Oncol.10(3),194-205(2012)
Ranieri, G., Gadaleta, C.D., Patruno, R., et al.A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapiesCrit. Rev. Oncol. Hematol.88,187-197(2013)
