Telatinib
Cat. No.：YN440104
CAS No. ：332012-40-5
规格
价格(RMB)
库存
| 产品名称: | Telatinib |
| CAS No.: | 332012-40-5 |
| Chemical Name: | 4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide |
| Synonyms: | Bay 57-9352 |
| 分子量: | 409.83 |
| 分子式: | C₂₀H₁₆ClN₅O₃ |
| SMILES: | O=C(C1=NC=CC(COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4)=C1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Telatinib是有口服活性的VEGFR2，VEGFR3，PDGFα和c-Kit的小分子抑制剂，IC50值分别为6，4，15，1 nM。 |
| IC50和靶点: | [{name:"VEGFR2:6 nM (IC50)"},{name: "VEGFR3:4 nM (IC50)"},{name: "PDGFRα:15 nM (IC50)"},{name: "c-Kit:1 nM (IC50)"}] |
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| Solvent & Solubility: |
Steeghs, N., Gelderblom, H., Roodt, J.O., et al.Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitorClin. Cancer Res.14(11),3470-3476(2008)
Sodani, K., Patel, A., Anreddy, N., et al.Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivoBiochem. Pharmacol.89(1),52-61(2014)
