Ripretinib
Cat. No.：YN440156
CAS No. ：1442472-39-0
规格
价格(RMB)
库存
| 产品名称: | Ripretinib |
| CAS No.: | 1442472-39-0 |
| Chemical Name: | N-[4-bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N′-phenyl-urea |
| Synonyms: | 瑞普替尼; DCC-2618 |
| 分子量: | 510.36 |
| 分子式: | C₂₄H₂₁BrFN₅O₂ |
| SMILES: | O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ripretinib (DCC-2618) 是一种口服生物利用的，选择性的KIT和PDGFRA开关控制抑制剂。Ripretinib (DCC-2618) 专门针对 KIT 和 PDGFRA 的野生型和突变型并与之结合在其开关口袋结合位点，从而防止这些激酶从无活性构象转变为有活性构象，并使它们的野生型和突变体形式失活。Ripretinib (DCC-2618) 还抑制多个其他激酶靶点，如FLT3，KDR (VEGFR-2)。Ripretinib (DCC-2618) 具有抗肿瘤作用并诱导细胞凋亡。 |
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Smith, B.D., Kaufman, M.D., Lu, W.-P., et al.Ripretinib (DCC-2618) is a switch control kinase inhibitor of a broad spectrum of oncogenic and drug-resistant KIT and PDGFRA variantsCancer Cell35(5),738-751(2019)
Schneeweiss, M., Peter, B., Bibi, S., et al.The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosisHaematologica103(5),799-809(2018)
