AZD3229
Cat. No.:YN440160
产品名称: | AZD3229 |
CAS No.: | 2248003-60-1 |
Chemical Name: | N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-1H-1,2,3-triazole-1-acetamide |
Synonyms: | AZD3229,AZD 3229,AZD-3229 |
分子量: | 479.51 |
分子式: | C₂₄H₂₆FN₇O₃ |
SMILES: | COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | AZD3229 是一种有效的、广泛的突变型酪氨酸激酶受体(KIT)抑制剂,可用于开发研究胃肠道间质瘤。 |
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Kettle, J.G., Anium, R., Barry, E., et al.Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a potent pan-KIT mutant Inhibitor for the treatment of gastrointestinal stromal tumorJ. Med. Chem.61(19),8797-8810(2018)