Cabozantinib
Cat. No.：YN440239
CAS No. ：849217-68-1
规格
价格(RMB)
库存
| 产品名称: | Cabozantinib |
| CAS No.: | 849217-68-1 |
| Chemical Name: | N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Synonyms: | 卡博替尼; XL184; BMS-907351 |
| 分子量: | 501.51 |
| 分子式: | C₂₈H₂₄FN₃O₅ |
| SMILES: | O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cabozantinib是一种有效的多受体酪氨酸激酶抑制剂， 抑制VEGFR2，c-Met，Kit，Axl和Flt3的IC50分别为0.035，1.3，4.6，7 和 11.3 nM。 |
| IC50和靶点: | [{name:"VEGFR2:0.035 nM (IC50)"},{name: "Flt-4:6 nM (IC50)"},{name: "Flt-1:12 nM (IC50)"},{name: "Met:1.3 ± 1.2 nM (IC50)"}] |
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| Solvent & Solubility: |
Yakes, F.M., Chen, J., Tan, J., et al.Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growthMol. Cancer Ther.10(12),2298-2308(2011)
Rausch, K., Hackett, B., Weinbren, N.R., S., et al.Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virusCell Rep.18(3),804-815(2017)
