AC710
Cat. No.：YN440274
CAS No. ：1351522-04-7
规格
价格(RMB)
库存
| 产品名称: | AC710 |
| CAS No.: | 1351522-04-7 |
| Chemical Name: | N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
| Synonyms: | AC710; AC 710; AC-710 |
| 分子量: | 562.70 |
| 分子式: | C₃₁H₄₂N₆O₄ |
| SMILES: | O=C(C1=NC=C(OC2CC(C)(C)N(CC)C(C)(C)C2)C=C1)NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AC710是有效的PDGFR抑制剂，对FLT3，CSF1R，KIT，PDGFRα 和 PDGFRβ的Kd值分别为0.6，1.57，1，1.3，1.0。 |
| IC50和靶点: | [{name:"PDGFRα:1.3 nM (Kd)"},{name: "PDGFRβ:1 nM (Kd)"},{name: "c-Kit:1 nM (Kd)"},{name: "FLT3:0.6 nM (Kd)"},{name: "CSF1R:1.57 nM (Kd)"}] |
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| Solvent & Solubility: |
Liu, G., Campbell, B.T., Holladay, M.W., et al.Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinasesACS Med. Chem. Lett.3(12),997-1002(2012)
