Tyrphostin AG1296
Cat. No.：YN440294
CAS No. ：146535-11-7
规格
价格(RMB)
库存
| 产品名称: | Tyrphostin AG1296 |
| CAS No.: | 146535-11-7 |
| Chemical Name: | 6,7-dimethoxy-2-phenyl-quinoxaline |
| Synonyms: | AG1296 |
| 分子量: | 266.29 |
| 分子式: | C₁₆H₁₄N₂O₂ |
| SMILES: | COC1=C(OC)C=C2N=CC(C3=CC=CC=C3)=NC2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tyrphostin AG1296 是一种有效的、选择性血小板衍生生长因子受体 (PDGFR) 抑制剂，IC50值为 0.8 μM。Tyrphostin AG1296 抑制人PDGF α和β受体以及相关干细胞因子受体 (c-Kit) 的信号传导。Tyrphostin AG1296 也是有效的FLT3抑制剂，IC50值在微摩尔范围内。 |
| IC50和靶点: | |
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Levitzki, A., and Gazit, A.Tyrosine kinase inhibition: An approach to drug developmentScience267(5205),1782-1788(1995)
Kovalenko, M., Gazit, A., Böhmer, A., et al.Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformationCancer Res.54(23),6106-6114(1994)
