Dovitinib
Cat. No.：YN440410
CAS No. ：405169-16-6
规格
价格(RMB)
库存
| 产品名称: | Dovitinib |
| CAS No.: | 405169-16-6 |
| Chemical Name: | 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone |
| Synonyms: | 多韦替尼; CHIR-258; TKI258 |
| 分子量: | 392.43 |
| 分子式: | C₂₁H₂₁FN₆O |
| SMILES: | O=C1NC(C=CC=C2F)=C2C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dovitinib (CHIR-258) 是多靶点的酪氨酸激酶抑制剂，抑制FLT3，c-Kit，FGFR1/3，VEGFR1/2/3和PDGFRα/β的IC50值分别为 1，2，8/9，10/13/8，27/210 nM。 |
| IC50和靶点: | [{name:"FLT3:1 nM (IC50)"},{name: "c-Kit:2 nM (IC50)"},{name: "FGFR1:8 nM (IC50)"},{name: "FGFR3:9 nM (IC50)"},{name: "VEGFR3:8 nM (IC50)"},{name: "VEGFR1:10 nM (IC50)"},{name: "VEGFR2:13 nM (IC50)"},{name: "PDGFRβ:27 nM (IC50)"},{name: "PDGFRα:210 nM (IC50)"},{name: "CSF-1R:36 nM (IC50)"}] |
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| Solvent & Solubility: |
Trudel, S., Li, Z.H., Wei, E., et al.CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myelomaBlood105(7),2941-2948(2005)
Renhowe, P.A., Pecchi, S., Shafer, C.M., et al.Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A novel class of receptor tyrosine kinase inhibitorsJ. Med. Chem.52(2),278-292(2009)
