NPS-1034
Cat. No.：YN440017
CAS No. ：1221713-92-3
规格
价格(RMB)
库存
| 产品名称: | NPS-1034 |
| CAS No.: | 1221713-92-3 |
| Chemical Name: | 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazole-4-carboxamide |
| Synonyms: | NPS 1034,NPS1034 |
| 分子量: | 551.54 |
| 分子式: | C₃₁H₂₃F₂N₅O₃ |
| SMILES: | O=C(C1=C(C)N(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NC=C5C6=CC=CC=C6)=NC=C4)C(F)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NPS-1034 是AXL和MET的双重抑制剂，其IC50值分别为 10.3 和 48 nM。 |
| IC50和靶点: | |
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Rho, J.K., Choi, Y.J., Kim, S.Y., et al.MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activationCancer Res.74(1),253-262(2014)
Shin, J.-S., Hong, S.-W., Moon, J.-H., et al.NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutantsInvest New Drugs32(3),389-399(2014)
