Foretinib
Cat. No.：YN440081
CAS No. ：849217-64-7
规格
价格(RMB)
库存
| 产品名称: | Foretinib |
| CAS No.: | 849217-64-7 |
| Chemical Name: | N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Synonyms: | XL880; GSK1363089; GSK089; EXEL-2880 |
| 分子量: | 632.65 |
| 分子式: | C₃₄H₃₄F₂N₄O₆ |
| SMILES: | O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Foretinib是一种多靶点酪氨酸激酶抑制剂，抑制Met和KDR的IC50分别为0.4 nM 和 0.9 nM。 |
| IC50和靶点: | [{name:"KDR:0.9 nM (IC50)"},{name: "c-Met:0.4 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Qian, F., Engst, S., Yamaguchi, K., et al.Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinasesCancer Res.69(20),8009-8016(2009)
Davis, M.I., Hunt, J.P., Herrgard, S., et al.Comprehensive analysis of kinase inhibitor selectivityNat. Biotechnol.29(11),1046-1051(2011)
Mughal, A., Aslam, H.M., Sheikh, A., et al.c-Met inhibitorsInfect. Agent. Cancer8,13(2013)
