MGCD-265 analog
Cat. No.：YN440132
CAS No. ：875337-44-3
规格
价格(RMB)
库存
| 产品名称: | MGCD-265 analog |
| CAS No.: | 875337-44-3 |
| Chemical Name: | N-[[[3-fluoro-4-[[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy]phenyl]amino]thioxomethyl]-benzeneacetamide |
| Synonyms: | Glesatinib,MGCD-265 |
| 分子量: | 517.60 |
| 分子式: | C₂₆H₂₀FN₅O₂S₂ |
| SMILES: | O=C(CC1=CC=CC=C1)NC(NC2=CC=C(C(F)=C2)OC3=C4C(C=C(S4)C5=CN(C=N5)C)=NC=C3)=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MGCD-265 analog 是一种高效的，具有口服活性的酪氨酸激酶c-Met和VEGFR2抑制剂，其IC50值分别为 29 nM 和 10 nM。MGCD-265 analog 具有显著的抗肿瘤活性。 |
| IC50和靶点: | [{name:"VEGFR2:10 nM (IC50)"},{name: "c-Met:29 nM (IC50)"}] |
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| Solvent & Solubility: |
Claridge, S., Raeppel, F., Granger, M.-C., et al.Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinasesBioorg. Med. Chem. Lett.18(9),2793-2798(2008)
Morgillo, F., Amendola, G., Corte, C.M.D., et al.Dual MET and SMO negative modulators overcome resistance to EGFR inhibitors in human nonsmall cell lung cancerJ. Med. Chem.60(17),7447-7458(2017)
