PHA-665752
Cat. No.：YN440141
CAS No. ：477575-56-7
规格
价格(RMB)
库存
| 产品名称: | PHA-665752 |
| CAS No.: | 477575-56-7 |
| Chemical Name: | (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | PHA665752,PHA 665752 |
| 分子量: | 641.61 |
| 分子式: | C₃₂H₃₄Cl₂N₄O₄S |
| SMILES: | O=C(C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(CC4=C(C=CC=C4Cl)Cl)=O)=O)=C1C)C)N5[C@H](CCC5)CN6CCCC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PHA-665752 是一种选择性的 ATP 竞争活性位点c-Met激酶抑制剂，Ki为 4 nM，IC50为 9 nM。PHA-665752 对 c-Met 的选择性比一组不同的酪氨酸和丝氨酸苏氨酸激酶高 50 倍。PHA-665752 诱导细胞凋亡和细胞周期阻滞，具有细胞还原性抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mughal, A., Aslam, H.M., Sheikh, A., et al.c-Met inhibitorsInfect. Agent. Cancer8,13(2013)
Christensen, J.G., Schreck, R., Burrows, J., et al.A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivoCancer Res.63(21),7345-7355(2003)
