Glumetinib
Cat. No.：YN440170
CAS No. ：1642581-63-2
规格
价格(RMB)
库存
| 产品名称: | Glumetinib |
| CAS No.: | 1642581-63-2 |
| Chemical Name: | 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-1H-pyrazolo[4,3-b]pyridine |
| Synonyms: | SCC244 |
| 分子量: | 459.48 |
| 分子式: | C₂₁H₁₇N₉O₂S |
| SMILES: | O=S(N1N=CC2=NC=C(C3=CN(C)N=C3)C=C21)(C4=CN=C5C=CC(C6=CN(C)N=C6)=CN54)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Glumetinib (SCC244) 是一种高选择性、口服生物利用度、ATP 竞争性c-Met抑制剂，IC50为0.42 nM。Glumetinib 对 c-Met 的选择性超过 312 种激酶，包括 c-Met 家族成员 RON 和高度同源的激酶 Axl、Mer、TyrO3。Glumetinib 具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ai, J., Chen, Y., Peng, X., et al.Preclinical evaluation of SCC244 (glumetinib), a novel, potent, and highly selective inhibitor of c-Met in MET-dependent cancer modelsMol. Cancer Ther.17(4),751-762(2017)
