SU11274
Cat. No.：YN440179
CAS No. ：658084-23-2
规格
价格(RMB)
库存
| 产品名称: | SU11274 |
| CAS No.: | 658084-23-2 |
| Chemical Name: | (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide |
| Synonyms: | PKI |
| 分子量: | 568.09 |
| 分子式: | C₂₈H₃₀ClN₅O₄S |
| SMILES: | O=S(C1=CC2=C(C=C1)NC(/C2=C/C3=C(C(C(N4CCN(CC4)C)=O)=C(N3)C)C)=O)(N(C)C5=CC=CC(Cl)=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SU11274 是一种选择性的Met抑制剂，IC50值为 10 nM，对 PGDFRβ，EGFR 或 Tie2 没有抑制作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mughal, A., Aslam, H.M., Sheikh, A., et al.c-Met inhibitorsInfect. Agent. Cancer8,13(2013)
Sattler, M., Pride, Y.B., Ma, P., et al.A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinaseCancer Res.63(17),5462-5469(2003)
Seiwert, T.Y., Jagadeeswaran, R., Faoro, L., et al.The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinomaCancer Res.69(7),3021-3031(2009)
