TAS-115 mesylate
Cat. No.：YN440209
CAS No. ：1688673-09-7
规格
价格(RMB)
库存
| 产品名称: | TAS-115 mesylate |
| CAS No.: | 1688673-09-7 |
| Chemical Name: | 4-[2-fluoro-4-[[[(2-phenylacetyl)amino]thioxomethyl]amino]phenoxy]-7-methoxy-N-methyl-6-quinolinecarboxamide, monomethanesulfonate |
| Synonyms: | TAS-115 methanesulfonate |
| 分子量: | 614.66 |
| 分子式: | C₂₈H₂₇FN₄O₇S₂ |
| SMILES: | CS(=O)(O)=O.O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC(CC4=CC=CC=C4)=O)=S)C=C3F)C2=C1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAS-115 mesylate是一种有效的VEGFR和肝细胞生长因子受体 (c-Met/HGFR) 的靶向激酶抑制剂，能够抑制 rVEGFR2 和 rMET 的活性，IC50值分别为 30 和 32 nM。 |
| IC50和靶点: | |
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Fujita, H., Miyadera, K., Kato, M., et al.The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profileMol. Cancer Ther.12(12),2685-2696(2013)
Koyama, K., Goto, H., Morizumi, S., et al.The tyrosine kinase inhibitor TAS-115 attenuates bleomycin-induced lung fibrosis in miceAm. J. Respir. Cell Mol. Biol.60(4),478-487(2019)
