Capmatinib
Cat. No.：YN440270
CAS No. ：1029712-80-8
规格
价格(RMB)
库存
| 产品名称: | Capmatinib |
| CAS No.: | 1029712-80-8 |
| Chemical Name: | 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-benzamide |
| Synonyms: | INC280; INCB28060 |
| 分子量: | 412.42 |
| 分子式: | C₂₃H₁₇FN₆O |
| SMILES: | O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Capmatinib (INC280; INCB28060) 是一种有效的，口服活性的，选择性的，ATP 竞争性的c-Met激酶抑制剂 (IC50=0.13 nM)。Capmatinib (INC280; INCB28060) 有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移，并有效诱导细胞凋亡。抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Liu, X., Wang, Q., Yang, G., et al.A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3Clin. Cancer. Res17(22),127-138(2011)
Brandes, F., Schmidt, K., Wagner, C., et al.Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer modelBMC Cancer15:71,(2015)
Moran-Jones, K., Brown, L.M., and Samimi, G.INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell modelsSci. Rep.5:11749,(2015)
