Savolitinib
Cat. No.：YN440353
CAS No. ：1313725-88-0
规格
价格(RMB)
库存
| 产品名称: | Savolitinib |
| CAS No.: | 1313725-88-0 |
| Chemical Name: | 1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine |
| Synonyms: | 沃利替尼; Volitinib; HMPL-504; AZD-6094 |
| 分子量: | 345.36 |
| 分子式: | C₁₇H₁₅N₉ |
| SMILES: | CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Savolitinib (AZD-6094) 是一种高效选择性、口服生物利用度c-Met抑制剂，对 c-Met 和 p-Met 的 IC50分别为 5 nM 和 3 nM。Savolitinib (AZD-6094) 以 ATP 竞争的方式选择性结合并抑制 c-Met 的激活，破坏 c-Met 信号转导途径。具有抗肿瘤活性。 |
| IC50和靶点: | |
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Jia, H., Dai, G., Weng, J., et al.Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancerJ. Med. Chem.57(18),7577-7589(2014)
Gavine, P.R., Ren, Y., Han, L., et al.Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft modelsMol. Oncol.9(1),323-333(2015)
