AMG-337
Cat. No.：YN440380
CAS No. ：1173699-31-4
规格
价格(RMB)
库存
| 产品名称: | AMG-337 |
| CAS No.: | 1173699-31-4 |
| Chemical Name: | 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one |
| Synonyms: | AMG337 |
| 分子量: | 463.46 |
| 分子式: | C₂₃H₂₂FN₇O₃ |
| SMILES: | O=C1C2=C(N=CC(OCCOC)=C2)C=CN1[C@@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG-337是一种有效的高度选择性的ATP竞争性MET激酶抑制剂, IC50 < 5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Boezio, A.A., Copeland, K.W., Rex, K., et al.Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a potent and selective inhibitor of MET with high unbound target coverage and robust in vivo antitumor activityJ. Med. Chem.59(6),2328-2342(2016)
Hughes, P.E., Rex, K., Caenepeel, S., et al.In vitro and in vivo activity of AMG 337, a potent and selective MET kinase inhibitor, in MET-dependent cancer modelsMol. Cancer Ther.15(7),1568-1579(2016)
Caenepeel, S., Cooke, K., Wadsworth, S., et al.MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factorOncotargetEpub ahead of print,(2017)
