JNJ-38877605
Cat. No.：YN440401
CAS No. ：943540-75-8
规格
价格(RMB)
库存
| 产品名称: | JNJ-38877605 |
| CAS No.: | 943540-75-8 |
| Chemical Name: | 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-quinoline |
| Synonyms: | JNJ38877605; JNJ-38877605 |
| 分子量: | 377.35 |
| 分子式: | C₁₉H₁₃F₂N₇ |
| SMILES: | FC(F)(C1=NN=C2C=CC(C3=CN(C)N=C3)=NN21)C4=CC5=C(N=CC=C5)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-38877605是ATP竞争性c-Met抑制剂，IC50为4 nM，对c-Met的抑制性比对其它200种酪氨酸和丝氨酸-苏氨酸激酶的抑制性要强600倍。 |
| IC50和靶点: | [{name:"c-Met:4 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Perera, T., Lavrijssen, T., Janssens, B., et al.JNJ-38877605: A selective Met kinase inhibitor inducing regression of Met-driven tumor modelsCancer Res.68(9Supp.),(2008)
Pennacchietti, S., Cazzanti, M., Bertotti, A., et al.Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugsCancer Res.74(22),6598-6609(2014)
De Bacco, F., Luraghi, P., Medico, E., et al.Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancerJ. Natl. Cancer Inst.103(8),645-661(2011)
Etnyre, D., Stone, A.L., Fong, J.T., et al.Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapyCancer Biol. Ther.15(9),1129-1141(2014)
