Tivantinib
Cat. No.：YN440402
CAS No. ：905854-02-6
规格
价格(RMB)
库存
| 产品名称: | Tivantinib |
| CAS No.: | 905854-02-6 |
| Chemical Name: | (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione |
| Synonyms: | ARQ 197 |
| 分子量: | 369.42 |
| 分子式: | C₂₃H₁₉N₃O₂ |
| SMILES: | O=C(NC1=O)[C@@H](C2=CN3C4=C(C=CC=C42)CCC3)[C@@H]1C5=CNC6=C5C=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tivantinib 是一种高选择性c-Met酪氨酸激酶抑制剂，Ki为 355 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Munshi, N., Jeay, S., Li, Y., et al.ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activityMol. Cancer Ther.9(6),1544-1553(2010)
Katayama, R., Aoyama, A., Yamori, T., et al.Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibitionCancer Res.73(10),3087-3096(2013)
