MK-2461
Cat. No.：YN440403
CAS No. ：917879-39-1
规格
价格(RMB)
库存
| 产品名称: | MK-2461 |
| CAS No.: | 917879-39-1 |
| Chemical Name: | N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N′-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-sulfamide |
| Synonyms: | MK2461 |
| 分子量: | 495.55 |
| 分子式: | C₂₄H₂₅N₅O₅S |
| SMILES: | O=S(N(C)C[C@H]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-2461是一种ATP竞争性的 c-Met 抑制剂, 平均 IC50 为2.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Katz, J.D., Jewell, J.P., Guerin, D.J., et al.Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancerJ. Med. Chem.54(12),4092-4108(2011)
Pan, B.-S., Chan, G.K.Y., Chenard, M., et al.MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptorCancer. Res.70(4),1524-1533(2010)
