LF3
Cat. No.：YN450019
CAS No. ：664969-54-4
规格
价格(RMB)
库存
| 产品名称: | LF3 |
| CAS No.: | 664969-54-4 |
| Chemical Name: | N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide |
| Synonyms: | N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide;LF-3;LF3 |
| 分子量: | 416.56 |
| 分子式: | C₂₀H₂₄N₄O₂S₂ |
| SMILES: | S=C(N1CCN(C/C=C/C2=CC=CC=C2)CC1)NC3=CC=C(S(=O)(N)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LF3是β-Catenin/TCF4相互作用的拮抗剂，具有抗肿瘤活性。IC50值为1.65 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Zhao, L., Sun, L., Lu, Y., et al.A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV 1.5 expression in HL-1 cardiomyocytesJ. Mol. Cell. Cardiol.135,90-96(2019)
Yu, Z., Jiang, X., Qin, L., et al.A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitinationOncogene40(5),1027-1042(2021)
Lei, Y., Yang, Q., Nie, Y., et al.Small-molecule inhibitor LF3 restrains the development of pulmonary hypertension through the Wnt/β-catenin pathwayActa Biochim Biophys. Sin. (Shanghai)53(10),(2021)
