XAV-939
Cat. No.：YN450094
CAS No. ：284028-89-3
规格
价格(RMB)
库存
| 产品名称: | XAV-939 |
| CAS No.: | 284028-89-3 |
| Chemical Name: | 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Synonyms: | NVP-XAV939 |
| 分子量: | 312.31 |
| 分子式: | C₁₄H₁₁F₃N₂OS |
| SMILES: | O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XAV-939 是有效的tankyrase抑制剂，靶向Wnt/β-catenin途径。XAV-939 通过 tankyrase 1 和 tankyrase 2 (IC50分别为 5 和 2 nM) 来稳定 axin，从而刺激 β-catenin 降解。XAV939 与 TNKS1 和 TNKS2 的催化 (PARP) 域紧密结合 (Kd分别为 99 和 93 nM)。 |
| IC50和靶点: | [{name:"TNKS2:2 nM (IC50)"},{name: "TNKS1:5 nM (IC50)"},{name: "ARTD2:479 nM (IC50)"},{name: "ARTD1:5500 nM (IC50)"}] |
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| Solvent & Solubility: |
Smith, S., Giriat, I., Schmitt, A., et al.Tankyrase, a poly(ADP-ribose) polymerase at human telomeresScience282,1484-1487(1998)
Huang, S.M.A., Mishina, Y.M., Liu, S., et al.Tankyrase inhibition stabilizes axin and antagonizes Wnt signallingNature461,614-619(2009)
