(E/Z)-4-Hydroxytamoxifen
Cat. No.：YN481570
CAS No. ：68392-35-8
| 产品名称: | (E/Z)-4-Hydroxytamoxifen |
| CAS No.: | 68392-35-8 |
| Chemical Name: | 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
| Synonyms: | (E/Z)-4-羟基他莫昔芬 |
| 分子量: | 387.51 |
| 分子式: | C₂₆H₂₉NO₂ |
| SMILES: | OC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E/Z)-4-Hydroxytamoxifen 是 (Z)-4-Hydroxytamoxifen 和 (E)-4-Hydroxytamoxifen 的消旋体。(E/Z)-4-Hydroxytamoxifen 是雌激素受体 (estrogen receptor) 调节剂。 |
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Desta, Z., Ward, B.A., Soukhova, N.V., et al.Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6J. Pharmacol. Exp. Ther.310(3),1062-1075(2004)
Seeger, H., Huober, J., Wallwiener, D., et al.Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifenHorm. Metab. Res.36(5),277-280(2004)
Duan, L., Danzer, B., Levenson, V.V., et al.Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cellsCancer Lett.353(2),290-300(2014)
